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12,21,22 The opening of the mitochondrial permeability transition pore under pathological conditions, such as oxidative stress, calcium overload, or energy depletion, leads to disruption of the mitochondrial membrane potential and the release of proapoptotic factors, ultimately culminating in cell death

Apixaban carries an FDA black-box warning for spinal/epidural hematoma risk in patients receiving neuraxial anesthesia or undergoing spinal procedures [1]

While this enzyme doesn't make glutathione, it is the tool that uses glutathione to neutralize hydrogen peroxide